Tamblyn appeared alongside Orlando Bloom, Colin Firth, and Patricia Clarkson in the 2010 film Main Street, a drama set in North Carolina.
That year, she also had a role in the drama 127 Hours, with James Franco.
Her uncle is Larry Tamblyn, who was the keyboardist in the 1960s rock band The Standells.
She was also nominated for a Saturn Award for Best Actress in a Television Series in 20.
Her first major film role was in 2005's The Sisterhood of the Traveling Pants, co-starring Alexis Bledel, America Ferrera, and Blake Lively.