Lowe played the role of Sodapop Curtis, the brother of the main character Ponyboy Curtis (C. In August, 1987 he performed on stage, playing Baron Tusenbach in Chekov's The Three Sisters at The Williamstown Theatre Festival.
He recalled meeting Paul Newman there, and that the older actor encouraged him to work in the theater, in 1993 when filming a British TV production of the Tennessee Williams play Suddenly Last Summer with Maggie Smith and Natasha Richardson.
In an episode broadcast on May 16, 2010, his character was part of a multi-vehicle crash involving a large truck and was put into a coma, the storyline was wrapped up in the first episode of the fifth season; Lowe did not appear in the episode.
In June 2006, he was the guest host for an episode in the third series of The Friday Night Project for the United Kingdom's Channel 4.
From 2015 to 2016, he starred alongside Fred Savage in The Grinder on FOX.