She followed it up with a role in Steven Spielberg's romantic comedy-drama Always (starring Richard Dreyfuss, Holly Hunter, and John Goodman), a modern version of the original 1943 Victor Fleming film A Guy Named Joe.
During the early to mid-1990s, Helgenberger played the love interest to Woody Harrelson's character in The Cowboy Way (1994), and had a small role as Capt.
Helgenberger got the chance to act with her husband, Alan Rosenberg, when he guest starred on CSI, Season 5 ("Weeping Willows") and Season 7 ("Leaving Las Vegas").
During her time on the show, Helgenberger acted in the feature film Erin Brockovich and portrayed Patsy Ramsey on the miniseries about the mysterious murder of 6-year-old beauty pageant contestant Jon Benét Ramsey in Perfect Murder, Perfect Town.
Helgenberger guest starred in an episode of the ABC series Spenser: For Hire, NBC's Matlock and ABC's thirtysomething.